Binding Avidity Influence Influenza Virus Antigenic Clustering

Single Hemagglutinin Mutations that Alter Both Antigenicity and Receptor 1 Binding Avidity Influence Influenza Virus Antigenic Clustering 2 Yang Li, David L. Bostick, Colleen B. Sullivan, Jaclyn L. Myers, Sara B. Griesemer, 3 Kirsten St. George, Joshua B. Plotkin, Scott E. Hensley 4 5 Wistar Vaccine Center, Wistar Institute, Philadelphia, PA 19104, USA 6 Department of Microbiology, The University of Pennsylvania, Philadelphia, PA 19104, USA 7 Department of Biology, The University of Pennsylvania, Philadelphia, PA 19104, USA 8 Laboratory of Viral Diseases, Wadsworth Center, New York State Department of Health, 9 Albany, NY 12208, USA 10 These authors contributed equally 11 Correspondence to SEH ([email protected]) or JBP ([email protected]) 12 13 Running title: Single HA mutations alter influenza clustering 14 Abstract word count: 246 15 Text word count: 3652 16 17 18 19 20 Correspondence to: 21 Scott E. Hensley, Ph.D. Joshua B. Plotkin, Ph.D. 22 418 Hill Pavilion 219 Lynch Labs 23 380 South University Ave 433 South University Ave 24 Philadelphia, PA 19104 Philadelphia, PA 19104 25 [email protected] [email protected] 26 P (215) 495-6864 P (215) 573-8052 27 F (215) 898-0709 F (215) 573-9454 28 29 30 31 Copyright © 2013, American Society for Microbiology. All Rights Reserved. J. Virol. doi:10.1128/JVI.01023-13 JVI Accepts, published online ahead of print on 3 July 2013